Cohesin Regulates MHC Class II Genes through Interactions with MHC Class II Insulators

Cohesin regulates MHC class II genes through interactions with MHC class II insulators.

Cohesin is a multiprotein, ringed complex that is most well-known for its role in stabilizing the association of sister chromatids between S phase and M. More recently, cohesin was found to be associated with transcriptional insulators, elements that are associated with the organization of chromatin into regulatory domains. The human MHC class II (MHC-II) locus contains 10 intergenic elements, ...

MHC class II tetramers.

MHC class II tetramers have emerged as an important tool for characterization of the specificity and phenotype of CD4 T cell immune responses, useful in a large variety of disease and vaccine studies. Issues of specific T cell frequency, biodistribution, and avidity, coupled with the large genetic diversity of potential class II restriction elements, require targeted experimental design. Transl...

Deregulated MHC Class II Transactivator

Acidosis Increases MHC Class II

Regulation of MHC Class II